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Blocking the glycine transporter SLC6A20 restored important brain signaling and improved social, communication, and repetitive behaviors in autism-related mouse models. The treatment also worked in human brain organoids and showed lasting effects in adult mice, suggesting the brain may remain more treatable later in life than previously thought.
The adult brain may be far better at repairing itself than scientists once believed. In mice, researchers discovered a special group of support cells called astrocytes that respond to damaged brain tissue by rebuilding lost cellular networks. Rather than simply moving into the injured area, these cells perform a remarkable maneuver: they create new nuclei and send them traveling through long cellular extensions to repopulate damaged regions.
Scientists have pinpointed a brain network—and its distinctive electrical rhythm—that appears to drive the benefits of deep brain stimulation for Parkinson’s disease. The discovery could lead to more precise, personalized stimulation settings and better results for patients.